| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-07-12 |
| タイトル |
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タイトル |
Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
kidney |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
landiolol hydrochloride |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
endothelin |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
endotoxemia |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
rat model |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
小倉, 吉保
荒井, サブリナ
山口, 直人
OKI, Masami
下條, 信威
Islam, Majedul
Khatun, Tanzila
神山, 純子
櫻本, 秀明
萩谷, 圭一
河野, 了
水谷, 太郎
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Aims
Endothelin (ET)-1 is the best known potent vasoconstrictor and has been implicated in pathogenesis of sepsis-associated acute kidney injury (AKI) in human or lipopolysaccharide (LPS)-induced AKI in animal models. We have previously shown that ET-1 is highly up-regulated in renal tissues and in plasma after LPS administration. Here, we investigated whether landiolol hydrochloride, an ultra-short-acting beta-blocker, can play an important role in ameliorating levels of LPS-induced up-regulation of renal HIF-1α–ET-1 system and inflammatory cytokines in a rat model of endotoxemia.
Main methods
Male Wistar rats at 8 weeks of age were either administered with: a) lipopolysaccharide (LPS) only for three hours (3 h) or b) LPS, followed by continuous administration of landiolol for 3 h; c) third group was only treated with vehicle.
Key findings
At 3 h after LPS administration there was: a) minimal injury in kidney tissues; b) circulatory levels of creatinine, blood urea nitrogen and NGAL increased and c) expression of inflammatory cytokines, such as TNF-α, IL-6 and iNOS increased at the level of both circulatory and renal tissues. In addition, LPS significantly induced renal expression of ET-1 and HIF-1α compared to control. Finally, treatment of LPS-administered rats with landiolol for 3 h normalized elevated serum markers of renal injury and up-regulated levels of renal HIF-1α–ET-1 system with normalization of TNF-α.
Significance
Taken together, these data led us to conclude that landiolol ameliorates the up-regulation of HIF-1α–ET-1 system in minimally morphologically-injured kidney and normalizes biomarkers of renal injury in early hours of endotoxemia of a rat model. |
|
言語 |
en |
| 書誌情報 |
en : Life sciences
巻 118,
号 2,
p. 347-356,
発行日 2014-11
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| 出版者 |
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出版者 |
Elsevier |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0024-3205 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00717011 |
| 権利 |
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言語 |
en |
|
権利情報 |
Copyright © 2014 The Authors. Published by Elsevier Inc. |
| 権利 |
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言語 |
en |
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権利情報 |
Under a Creative Commons license Attribution-NonCommercial-NoDerivs 4.0 Unported (CC BY-NC-ND 4.0) |
| 他の資源との関係 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.lfs.2014.05.007 |
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言語 |
en |
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関連名称 |
Science Direct(Elsevier) |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
本文 (772.9 kB)
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