{"created":"2023-06-19T13:30:54.353078+00:00","id":843,"links":{},"metadata":{"_buckets":{"deposit":"0f60cc7f-11e4-4b5b-8f2c-228f05cdfe0e"},"_deposit":{"created_by":14,"id":"843","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"843"},"status":"published"},"_oai":{"id":"oai:jrckicn.repo.nii.ac.jp:00000843","sets":["15"]},"author_link":["1616","1633","1656","1620","1654","1629","1622","1617","1636","1618","1623","1655"],"control_number":"843","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"356","bibliographicPageStart":"347","bibliographicVolumeNumber":"118","bibliographic_titles":[{"bibliographic_title":"Life sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims\nEndothelin (ET)-1 is the best known potent vasoconstrictor and has been implicated in pathogenesis of sepsis-associated acute kidney injury (AKI) in human or lipopolysaccharide (LPS)-induced AKI in animal models. We have previously shown that ET-1 is highly up-regulated in renal tissues and in plasma after LPS administration. Here, we investigated whether landiolol hydrochloride, an ultra-short-acting beta-blocker, can play an important role in ameliorating levels of LPS-induced up-regulation of renal HIF-1α–ET-1 system and inflammatory cytokines in a rat model of endotoxemia.\n\nMain methods\nMale Wistar rats at 8 weeks of age were either administered with: a) lipopolysaccharide (LPS) only for three hours (3 h) or b) LPS, followed by continuous administration of landiolol for 3 h; c) third group was only treated with vehicle.\n\nKey findings\nAt 3 h after LPS administration there was: a) minimal injury in kidney tissues; b) circulatory levels of creatinine, blood urea nitrogen and NGAL increased and c) expression of inflammatory cytokines, such as TNF-α, IL-6 and iNOS increased at the level of both circulatory and renal tissues. In addition, LPS significantly induced renal expression of ET-1 and HIF-1α compared to control. Finally, treatment of LPS-administered rats with landiolol for 3 h normalized elevated serum markers of renal injury and up-regulated levels of renal HIF-1α–ET-1 system with normalization of TNF-α.\n\nSignificance\nTaken together, these data led us to conclude that landiolol ameliorates the up-regulation of HIF-1α–ET-1 system in minimally morphologically-injured kidney and normalizes biomarkers of renal injury in early hours of endotoxemia of a rat model.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Science Direct(Elsevier)"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.lfs.2014.05.007","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2014 The Authors. Published by Elsevier Inc."},{"subitem_rights":"Under a Creative Commons license Attribution-NonCommercial-NoDerivs 4.0 Unported (CC BY-NC-ND 4.0)"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00717011","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0024-3205","subitem_source_identifier_type":"PISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OGURA, Yoshiyasu","creatorNameLang":"en"},{"creatorName":"オグラ, ヨシヤス","creatorNameLang":"ja-Kana"},{"creatorName":"小倉, 吉保","creatorNameLang":"ja"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jesmin, Subrina","creatorNameLang":"en"},{"creatorName":"荒井, サブリナ","creatorNameLang":"ja"},{"creatorName":"アライ, サブリナ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMAGUCHI, Naoto","creatorNameLang":"en"},{"creatorName":"山口, 直人","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, ナオト","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"OKI, Masami","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SIMOJO, Nobutake","creatorNameLang":"en"},{"creatorName":"下條, 信威","creatorNameLang":"ja"},{"creatorName":"シモジョウ, ノブタケ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Islam, Majedul","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Khatun, Tanzila","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAMIYAMA, Junko","creatorNameLang":"en"},{"creatorName":"神山, 純子","creatorNameLang":"ja"},{"creatorName":"カミヤマ, ジュンコ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAKURAMOTO, Hideaki","creatorNameLang":"en"},{"creatorName":"櫻本, 秀明","creatorNameLang":"ja"},{"creatorName":"サクラモト, ヒデアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"萩谷, 圭一","creatorNameLang":"ja"},{"creatorName":"HAGIYA, Keiichi","creatorNameLang":"en"},{"creatorName":"ハギヤ, ケイイチ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWANO, Satoru","creatorNameLang":"en"},{"creatorName":"河野, 了","creatorNameLang":"ja"},{"creatorName":"カワノ, サトル","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIZUTANI, Taro","creatorNameLang":"en"},{"creatorName":"水谷, 太郎","creatorNameLang":"ja"},{"creatorName":"ミズタニ, タロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-12"}],"displaytype":"detail","filename":"Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia.pdf","filesize":[{"value":"772.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文","url":"https://jrckicn.repo.nii.ac.jp/record/843/files/Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia.pdf"},"version_id":"7233b09e-53de-4531-8dc3-7f3fe66585bc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"kidney","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"landiolol hydrochloride","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endotoxemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat model","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"14","path":["15"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-07-12"},"publish_date":"2022-07-12","publish_status":"0","recid":"843","relation_version_is_last":true,"title":["Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2024-02-02T06:41:11.463248+00:00"}