@article{oai:jrckicn.repo.nii.ac.jp:00000843,
 author = {OGURA, Yoshiyasu and 小倉, 吉保 and Jesmin, Subrina and 荒井, サブリナ and YAMAGUCHI, Naoto and 山口, 直人 and OKI, Masami and SIMOJO, Nobutake and 下條, 信威 and Islam, Majedul and Khatun, Tanzila and KAMIYAMA, Junko and 神山, 純子 and SAKURAMOTO, Hideaki and 櫻本, 秀明 and 萩谷, 圭一 and HAGIYA, Keiichi and KAWANO, Satoru and 河野, 了 and MIZUTANI, Taro and 水谷, 太郎},
 issue = {2},
 journal = {Life sciences},
 month = {Nov},
 note = {application/pdf, Aims
Endothelin (ET)-1 is the best known potent vasoconstrictor and has been implicated in pathogenesis of sepsis-associated acute kidney injury (AKI) in human or lipopolysaccharide (LPS)-induced AKI in animal models. We have previously shown that ET-1 is highly up-regulated in renal tissues and in plasma after LPS administration. Here, we investigated whether landiolol hydrochloride, an ultra-short-acting beta-blocker, can play an important role in ameliorating levels of LPS-induced up-regulation of renal HIF-1α–ET-1 system and inflammatory cytokines in a rat model of endotoxemia.

Main methods
Male Wistar rats at 8 weeks of age were either administered with: a) lipopolysaccharide (LPS) only for three hours (3 h) or b) LPS, followed by continuous administration of landiolol for 3 h; c) third group was only treated with vehicle.

Key findings
At 3 h after LPS administration there was: a) minimal injury in kidney tissues; b) circulatory levels of creatinine, blood urea nitrogen and NGAL increased and c) expression of inflammatory cytokines, such as TNF-α, IL-6 and iNOS increased at the level of both circulatory and renal tissues. In addition, LPS significantly induced renal expression of ET-1 and HIF-1α compared to control. Finally, treatment of LPS-administered rats with landiolol for 3 h normalized elevated serum markers of renal injury and up-regulated levels of renal HIF-1α–ET-1 system with normalization of TNF-α.

Significance
Taken together, these data led us to conclude that landiolol ameliorates the up-regulation of HIF-1α–ET-1 system in minimally morphologically-injured kidney and normalizes biomarkers of renal injury in early hours of endotoxemia of a rat model.},
 pages = {347--356},
 title = {Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia},
 volume = {118},
 year = {2014},
 yomi = {オグラ, ヨシヤス and アライ, サブリナ and ヤマグチ, ナオト and シモジョウ, ノブタケ and カミヤマ, ジュンコ and サクラモト, ヒデアキ and ハギヤ, ケイイチ and カワノ, サトル and ミズタニ, タロウ}
}