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  1. 雑誌掲載論文(国外)

Early Light Sedation Increased the Duration of Mechanical Ventilation in Patients With Severe Lung Injury

https://jrckicn.repo.nii.ac.jp/records/2000018
https://jrckicn.repo.nii.ac.jp/records/2000018
751b5d25-95c6-4698-98be-3f760bf048fd
Item type 学術雑誌論文 / Journal Article(1)
公開日 2024-01-19
タイトル
タイトル Early Light Sedation Increased the Duration of Mechanical Ventilation in Patients With Severe Lung Injury
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 acute physiology and chronic health evaluation II score
キーワード
言語 en
主題Scheme Other
主題 deep sedation
キーワード
言語 en
主題Scheme Other
主題 intensive care unit
キーワード
言語 en
主題Scheme Other
主題 tidal volume
キーワード
言語 en
主題Scheme Other
主題 ventilator
キーワード
言語 en
主題Scheme Other
主題 ventilator-induced lung injury
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 鳩崎, 千絵

× 鳩崎, 千絵

en HATOZAKI, Chie

ja 鳩崎, 千絵

ja-Kana ハトザキ, チエ


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櫻本, 秀明

× 櫻本, 秀明

en SAKURAMOTO, Hideaki

ja 櫻本, 秀明

ja-Kana サクラモト, ヒデアキ


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大内, 玲

× 大内, 玲

ja 大内, 玲

en OUCHI, Akira

ja-Kana オオウチ, アキラ


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下條, 信威

× 下條, 信威

en SIMOJO, Nobutake

ja 下條, 信威

ja-Kana シモジョウ, ノブタケ


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井上, 貴昭

× 井上, 貴昭

ja 井上, 貴昭

en INOUE, Yoshiaki

ja-Kana イノウエ, ヨシアキ


Search repository
抄録
内容記述タイプ Abstract
内容記述 Introduction: The international guidelines recommend light sedation management for patients receiving mechanical ventilation. One of the benefits of light sedation management during mechanical ventilation is the preservation of spontaneous breathing, which leads to improved gas-exchange and patient outcomes. Conversely, recent experimental animal studies have suggested that strong spontaneous breathing effort may cause worsening of lung injury, especially in severe lung injury cases. The association between depth of sedation and patient outcomes may depend on the severity of lung injury.
Objective: This study aimed to describe the patients’ clinical outcomes under deep or light sedation during the first 48 h of mechanical ventilation and investigate the association of light sedation on patient outcomes for each severity of lung injury.
Methods: The researchers performed a retrospective observational study at a university hospital in Japan. Patients aged ≥20 years, who received mechanical ventilation for at least 48 h were enrolled.
Results: A total of 413 patient cases were analyzed. Light sedation was associated with significantly shorter 28-day ventilator-free days compared with deep sedation in patients with severe lung injury (0 [IQR 0–5] days vs. 16 [0–19] days, P = .038). In the groups of patients with moderate and mild lung injury, the sedation depth was not associated with ventilator-free days. After adjusting for the positive end-expiratory pressure and APACHE II score, it was found that light sedation decreased the number of ventilator-free days in patients with severe lung injury (−10.8 days, 95% CI −19.2 to −2.5, P = .012).
Conclusion: Early light sedation for severe lung injury may be associated with fewer ventilator-free days.
言語 en
書誌情報 en : SAGE Open Nursing

巻 9, p. 23779608231206700, 発行日 2023
出版者
出版者 SAGE Publications
ISSN
収録物識別子タイプ EISSN
収録物識別子 2377-9608
権利
言語 en
権利情報 © The Author(s) 2023.
権利
言語 en
権利情報 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
他の資源との関係
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1177/23779608231206761
言語 en
関連名称 Cite article: Hatozaki C, Sakuramoto H, Ouchi A, Shimojo N, Inoue Y. Early Light Sedation Increased the Duration of Mechanical Ventilation in Patients With Severe Lung Injury. SAGE Open Nursing. 2023;9. doi:10.1177/23779608231206761
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内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
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