| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-07-13 |
| タイトル |
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タイトル |
Effects of Closed Vs. Open Repeated Endotracheal Suctioning During Mechanical Ventilation on the Pulmonary and Circulatory Levels of Endothelin-1 in Lavage-Induced Rabbit ARDS Model |
| タイトル |
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タイトル |
Effects of Closed Vs. Open Repeated Endotracheal Suctioning During Mechanical Ventilation on the Pulmonary and Circulatory Levels of Endothelin-1 in Lavage-Induced Rabbit ARDS Model |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
acute respiratory distress syndrome |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
endotracheal suctioning |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
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主題 |
endothelin-1 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
櫻本, 秀明
荒井, サブリナ
下條, 信威
神山, 純子
宮, 顕
Islam, Majedul
Khatun, Tanzila
河野, 了
水谷, 太郎
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: A growing body of evidence demonstrates discretely the difference of open endotracheal suctioning (OES) and closed endotracheal suctioning (CES) on the respiratory and hemodynamic parameters in acute respiratory distress syndrome (ARDS). Endothelin-1 (ET-1), a mediator of vascular inflammation, cell proliferation, and fibrosis in addition to being a potent vasoconstrictor has been potentially implicated in the pathogenesis of ARDS. Here, we investigated the effects of repeated OES vs. CES during mechanical ventilation on circulatory and pulmonary levels of ET-1 in ARDS. Methods: Briefly, 22 Japanese White Rabbits were intubated with a 3.5-mm endotracheal tube. Normal saline was instilled into lung and washed mildly. After instillation, rabbits were ventilated at definite setting; OES and CES duration was for 6 hours and performed every 30 minutes from protocol start. Results: At circulatory level, either OES or CES did not alter plasma ET-1 level compared to the ET-1 level in ARDS before the initiation of endotracheal suctioning (OES 4.7 ± 1.3 pg/ml vs. CES 4.8 ± 1.5 pg/ml, p=0.839). In contrast, pulmonary ET-1 level was significantly higher in CES group compared to OES group after 6 hours of repeated suctioning in ARDS (OES 26.9 ± 2.2 pg/mg vs. CES 29.9 ± 3.3 pg/mg, p=0.018). This change in pulmonary ET-1 level could maintain a parallel relation with PaO2 level. Conclusion: At this moment, we cannot clarify the mechanism and effects of the observed change in ET-1 in a rabbit model of ARDS as well as its clinical impact. |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Research Article |
| 書誌情報 |
Journal of Vascular Medicine & Surgery
en : Journal of Vascular Medicine & Surgery
巻 2,
p. 127,
発行日 2014
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| 出版者 |
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出版者 |
Walsh Medical Media |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
23296925 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.4172/2329-6925.1000127 |
| 権利 |
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権利情報 |
© 2014 Sakuramoto H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://www.walshmedicalmedia.com/open-access/effects-of-closed-vs-open-repeated-endotracheal-suctioning-during-mechanical-ventilation-on-the-pulmonary-and-circulator-9007.html |
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関連名称 |
Walsh Medical Media |
| 他の資源との関係 |
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関連名称 |
isIdenticalTo:https://doi.org/10.4172/2329-6925.1000127 |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
本文 (422.9 kB)
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