| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-07-12 |
| タイトル |
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タイトル |
Dual blockade of endothelin action exacerbates up-regulated VEGF angiogenic signaling in the heart of lipopolysaccharide-induced endotoxemic rat model |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
endotoxemic heart |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lipopolysaccharide |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
vascular endothelial growth factor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
endothelin receptor antagonist (SB-209670) |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
OKI, Masami
荒井, サブリナ
Islam, Majedul
Mowa, Chishimba Nathan
Khatun, Tanzila
下條, 信威
櫻本, 秀明
神山, 純子
河野, 了
宮内, 卓
水谷, 太郎
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Aims
Sepsis is a cluster of heterogeneous syndromes associated with progressive endotoxemic developments, ultimately leading to damage of multiple organs, including the heart. However, the pathogenesis of sepsis-induced myocardial dysfunction is still not fully understood. The present study is the first to examine alterations in expression of key angiogenic signaling system mediated by vascular endothelial growth factor (VEGF) in septic heart and the effects of endothelin dual blocker (ETDB) on it.
Main methods
Normal Wistar rats were either administered with: a) vehicle only (control group), b) lipopolysaccharide only (LPS: 15 mg/kg) and then sacrificed at different time points (1 h, 3 h, 6 h and 10 h), and c) the last group was co-administered with LPS and ETDB (SB-209670, 1 mg/kg body weight) for 6 h and then sacrificed.
Key findings
Administration of LPS resulted in increases in levels of: a) serum tumor necrosis factor (TNF)-α, b) serum VEGF and c) serum endothelin (ET)-1 levels accompanied by up-regulation of cardiac VEGF and its downstream angiogenic signaling molecules. While cardiac TNF-α level was unchanged among experimental groups, cardiac ET-1 level was significantly higher in LPS-administered group.
Significance
We conclude that elevation in VEGF angiogenic signaling may be triggered by diminished oxygenation in the myocardium following LPS administration as a consequence of sepsis-induced microvascular dysfunction. Because of this cardiac dysfunction, oxygen supply may be inadequate at microregional level to support the normal heart metabolism and function. ETDB at 6 h further increased the elevated levels of VEGF angiogenic signaling in endotoxemic heart. |
|
言語 |
en |
| 書誌情報 |
en : Life sciences
巻 118,
号 2,
p. 364-369,
発行日 2014-11
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| 出版者 |
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出版者 |
Elsevier |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0024-3205 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00717011 |
| 権利 |
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|
言語 |
en |
|
権利情報 |
Copyright © 2014 The Authors. Published by Elsevier Inc. |
| 権利 |
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言語 |
en |
|
権利情報 |
Under a Creative Commons license Attribution-NonCommercial-NoDerivs 4.0 Unported (CC BY-NC-ND 4.0) |
| 他の資源との関係 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.lfs.2014.02.008 |
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言語 |
en |
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|
関連名称 |
Science Direct(Elsevier) |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
本文 (441.7 kB)
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