| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-07-12 |
| タイトル |
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|
タイトル |
Hyperinflation deteriorates arterial oxygenation and lung injury in a rabbit model of ARDS with repeated open endotracheal suctioning |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
ARDS |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
open endotracheal suctioning |
| キーワード |
|
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
hyperinflation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
arterial oxygenation |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
TNF-α |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL-8 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
神山, 純子
荒井, サブリナ
櫻本, 秀明
下條, 信威
Islam, Majedul
萩谷, 圭一
菅野, 雅人
卯野木, 健
OKI, Masami
河野, 了
水谷, 太郎
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background
Hyperinflation (HI) is performed following open endotracheal suctioning (OES), whose goals include: to stimulate a cough, recover oxygenation and improve compliance. However, it may also induce unintended consequences, including: lung stress and strain, failure to maintain high distending pressure, and subsequently cycling recruitment and derecruitment. Here, our aim was to investigate the effects of hyperinflation after repeated OES on sequential alteration of arterial oxygenation and lung injury profile using a saline lavage-induced surfactant depleted ARDS rabbit model.
Methods
Briefly, 30 Japanese White Rabbits were anesthetized and ventilated in pressure-controlled setting with a tidal volume of 6-8 ml/kg. Animals were divided into four groups, i.e.; Control, ARDS, OES, and HI. Saline-lavage-induced lung injury was induced except for Control group. Thereafter, rabbits were ventilated with positive-end expiratory pressure (PEEP) at 10 cm H2O. The ARDS group received ventilation with the same PEEP without derecruitment. As intervention, OES and HI were performed in ARDS animals. OES was performed for 15 seconds at 150 mm Hg, whereas HI was performed with PEEP at 0 cm H2O and peak inspiratory pressure at +5 cm H2O for a minute. Total duration of the experiment was for 3 hours. OES and HI were performed every 15 minutes from beginning of the protocol.
Results
PaO2 was maintained at about 400 mm Hg in both control and ARDS groups for the duration of this study, while in both OES and HI groups, PaO2 decreased continuously up to 3 hours, dropped to a mean (±SD) of 226 ± 28.9 and 97.0 ± 30.7 mmHg at 3 h, respectively. HI group had the lowest PaO2 in the present investigation. Histological lung injury score was the highest in HI group than other three groups. Pulmonary TNF-α and IL-8 levels were the highest in HI group compared to other groups, but without significant alterations at circulatory level in all the experimental groups.
Conclusions
We show in the present study that hyperinflation following repeated OES deteriorate arterial oxygenation and the severity of lung injury in a rabbit model of ARDS undergoing mechanical ventilation. |
|
言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
Research article |
|
言語 |
en |
| 書誌情報 |
en : BMC anesthesiology
号 15,
p. 73,
発行日 2015-05
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| 出版者 |
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出版者 |
BioMed Central |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1471-2253 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12034694 |
| 権利 |
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言語 |
en |
|
権利情報 |
© 2015 Kamiyama et al.; licensee BioMed Central. |
| 権利 |
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言語 |
en |
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| 他の資源との関係 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s12871-015-0045-5 |
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言語 |
en |
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関連名称 |
BMC(Springer Nature) |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
本文 (912.1 kB)
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