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  1. 雑誌掲載論文(国外)

Repeated open endotracheal suctioning causes gradual desaturation but does not exacerbate lung injury compared to closed endotracheal suctioning in a rabbit model of ARDS

https://jrckicn.repo.nii.ac.jp/records/840
https://jrckicn.repo.nii.ac.jp/records/840
68f01a6d-ad48-4a09-b8b4-bf2862b1b795
名前 / ファイル ライセンス アクション
Repeated 本文 (494.7 kB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-07-11
タイトル
タイトル Repeated open endotracheal suctioning causes gradual desaturation but does not exacerbate lung injury compared to closed endotracheal suctioning in a rabbit model of ARDS
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 acute respiratory distress syndrome
キーワード
言語 en
主題Scheme Other
主題 lung injury
キーワード
言語 en
主題Scheme Other
主題 repeated endotracheal suctioning
キーワード
言語 en
主題Scheme Other
主題 repeated derecruitments
キーワード
言語 en
主題Scheme Other
主題 mechanical ventilation
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 櫻本, 秀明

× 櫻本, 秀明

en SAKURAMOTO, Hideaki

ja 櫻本, 秀明

ja-Kana サクラモト, ヒデアキ


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下條, 信威

× 下條, 信威

en SIMOJO, Nobutake

ja 下條, 信威

ja-Kana シモジョウ, ノブタケ


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荒井, サブリナ

× 荒井, サブリナ

en Jesmin, Subrina

ja 荒井, サブリナ

ja-Kana アライ, サブリナ


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卯野木, 健

× 卯野木, 健

en UNOKI, Takeshi

ja 卯野木, 健

ja-Kana ウノキ, タケシ


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神山, 純子

× 神山, 純子

en KAMIYAMA, Junko

ja 神山, 純子

ja-Kana カミヤマ, ジュンコ


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OKI, Masami

× OKI, Masami

en OKI, Masami


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宮, 顕

× 宮, 顕

ja 宮, 顕

en MIYA, Ken

ja-Kana ミヤ, ケン


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河野, 了

× 河野, 了

en KAWANO, Satoru

ja 河野, 了

ja-Kana カワノ, サトル


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水谷, 太郎

× 水谷, 太郎

en MIZUTANI, Taro

ja 水谷, 太郎

ja-Kana ミズタニ, タロウ


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抄録
内容記述タイプ Abstract
内容記述 Background
Although endotracheal suctioning induces alveolar derecruitment during mechanical ventilation, it is not clear whether repeated endotracheal suctioning exacerbates lung injuries. The present study aimed to determine whether repeated open endotracheal suctioning (OS) exacerbates lung injury compared to closed endotracheal suctioning (CS) during mechanical ventilation in an animal model of acute respiratory distress syndrome (ARDS).

Methods
Briefly, thirty six Japanese white rabbits were initially ventilated in pressure-controlled mode with a constant tidal volume (6 mL/kg). Then, lung injury was induced by repeated saline lavage. The rabbits were divided into four groups, namely: a) OS; b) CS; c) control with ARDS only; d) and healthy control (HC) without ARDS. Animals in all the groups were then ventilated with positive end expiratory pressure (PEEP) at 10 cm H2O. CS was performed using 6 French-closed suctioning catheters connected to endotracheal tube under the following conditions: a) a suctioning time and pressure of 10 sec and 140 mm Hg, respectively; and b) a suction depth of 2 cm (length of adapter) plus tracheal tube. OS was performed using the same conditions described for CS, except the ventilator was disconnected from the animals. Each endotracheal suctioning was performed at an interval of 30 min.

Results
PaO2/FIO2 (P/F) ratio for CS, control and HC groups remained at >400 for 6 hours, whereas that of the OS group progressively declined to 300 (p < 0.05), with each suctioning. However, no difference was observed either in lung injury score (histology) or in the expression pattern of inflammatory cytokines (tumor necrosis factor-α and interleukin-6) after 6 hours between the OS and CS groups in the circulatory as well as the pulmonary tissues.

Conclusions
Progressive arterial desaturation under conditions of repeated endotracheal suctioning is greater in OS than in CS time-dependently. However, OS does not exacerbate lung injury during mechanical ventilation when observed over a longer time span (6 hours) of repeated endotracheal suctioning, based on morphological and molecular analysis.
言語 en
書誌情報 en : BMC anesthesiology

号 13, p. 47, 発行日 2013-12
出版者
出版者 BioMed Central
ISSN
収録物識別子タイプ EISSN
収録物識別子 1471-2253
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12034694
権利
言語 en
権利情報 © 2013 Sakuramoto et al.; licensee BioMed Central Ltd.
権利
言語 en
権利情報 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
関連サイト
関連名称 BMC(Springer Nature)
他の資源との関係
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/1471-2253-13-47
言語 en
関連名称 BMC(Springer Nature)
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
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