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The present study aimed to determine whether repeated open endotracheal suctioning (OS) exacerbates lung injury compared to closed endotracheal suctioning (CS) during mechanical ventilation in an animal model of acute respiratory distress syndrome (ARDS).\n\nMethods\nBriefly, thirty six Japanese white rabbits were initially ventilated in pressure-controlled mode with a constant tidal volume (6 mL/kg). Then, lung injury was induced by repeated saline lavage. The rabbits were divided into four groups, namely: a) OS; b) CS; c) control with ARDS only; d) and healthy control (HC) without ARDS. Animals in all the groups were then ventilated with positive end expiratory pressure (PEEP) at 10 cm H2O. CS was performed using 6 French-closed suctioning catheters connected to endotracheal tube under the following conditions: a) a suctioning time and pressure of 10 sec and 140 mm Hg, respectively; and b) a suction depth of 2 cm (length of adapter) plus tracheal tube. OS was performed using the same conditions described for CS, except the ventilator was disconnected from the animals. Each endotracheal suctioning was performed at an interval of 30 min.\n\nResults\nPaO2/FIO2 (P/F) ratio for CS, control and HC groups remained at \u003e400 for 6 hours, whereas that of the OS group progressively declined to 300 (p \u003c 0.05), with each suctioning. However, no difference was observed either in lung injury score (histology) or in the expression pattern of inflammatory cytokines (tumor necrosis factor-α and interleukin-6) after 6 hours between the OS and CS groups in the circulatory as well as the pulmonary tissues.\n\nConclusions\nProgressive arterial desaturation under conditions of repeated endotracheal suctioning is greater in OS than in CS time-dependently. However, OS does not exacerbate lung injury during mechanical ventilation when observed over a longer time span (6 hours) of repeated endotracheal suctioning, based on morphological and molecular analysis.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "BioMed Central", "subitem_publisher_language": "en"}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "BMC(Springer Nature)"}]}]}, "item_10001_relation_18": {"attribute_name": "他の資源との関係", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_language": "en", "subitem_relation_name_text": "BMC(Springer Nature)"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1186/1471-2253-13-47", "subitem_relation_type_select": 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Repeated open endotracheal suctioning causes gradual desaturation but does not exacerbate lung injury compared to closed endotracheal suctioning in a rabbit model of ARDS
https://jrckicn.repo.nii.ac.jp/records/840
https://jrckicn.repo.nii.ac.jp/records/84068f01a6d-ad48-4a09-b8b4-bf2862b1b795
名前 / ファイル | ライセンス | アクション |
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本文 (494.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-07-11 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Repeated open endotracheal suctioning causes gradual desaturation but does not exacerbate lung injury compared to closed endotracheal suctioning in a rabbit model of ARDS | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | acute respiratory distress syndrome | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | lung injury | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | repeated endotracheal suctioning | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | repeated derecruitments | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mechanical ventilation | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
櫻本, 秀明
× 櫻本, 秀明× 下條, 信威× 荒井, サブリナ× 卯野木, 健× 神山, 純子× OKI, Masami× 宮, 顕× 河野, 了× 水谷, 太郎 |
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抄録 | ||||||
内容記述 | Background Although endotracheal suctioning induces alveolar derecruitment during mechanical ventilation, it is not clear whether repeated endotracheal suctioning exacerbates lung injuries. The present study aimed to determine whether repeated open endotracheal suctioning (OS) exacerbates lung injury compared to closed endotracheal suctioning (CS) during mechanical ventilation in an animal model of acute respiratory distress syndrome (ARDS). Methods Briefly, thirty six Japanese white rabbits were initially ventilated in pressure-controlled mode with a constant tidal volume (6 mL/kg). Then, lung injury was induced by repeated saline lavage. The rabbits were divided into four groups, namely: a) OS; b) CS; c) control with ARDS only; d) and healthy control (HC) without ARDS. Animals in all the groups were then ventilated with positive end expiratory pressure (PEEP) at 10 cm H2O. CS was performed using 6 French-closed suctioning catheters connected to endotracheal tube under the following conditions: a) a suctioning time and pressure of 10 sec and 140 mm Hg, respectively; and b) a suction depth of 2 cm (length of adapter) plus tracheal tube. OS was performed using the same conditions described for CS, except the ventilator was disconnected from the animals. Each endotracheal suctioning was performed at an interval of 30 min. Results PaO2/FIO2 (P/F) ratio for CS, control and HC groups remained at >400 for 6 hours, whereas that of the OS group progressively declined to 300 (p < 0.05), with each suctioning. However, no difference was observed either in lung injury score (histology) or in the expression pattern of inflammatory cytokines (tumor necrosis factor-α and interleukin-6) after 6 hours between the OS and CS groups in the circulatory as well as the pulmonary tissues. Conclusions Progressive arterial desaturation under conditions of repeated endotracheal suctioning is greater in OS than in CS time-dependently. However, OS does not exacerbate lung injury during mechanical ventilation when observed over a longer time span (6 hours) of repeated endotracheal suctioning, based on morphological and molecular analysis. |
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書誌情報 |
en : BMC anesthesiology 号 13, p. 47, 発行日 2013-12 |
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出版者 | ||||||
出版者 | BioMed Central | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1471-2253 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12034694 | |||||
権利 | ||||||
権利情報 | © 2013 Sakuramoto et al.; licensee BioMed Central Ltd. | |||||
権利 | ||||||
権利情報 | This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
関連サイト | ||||||
関連名称 | BMC(Springer Nature) | |||||
他の資源との関係 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1186/1471-2253-13-47 | |||||
関連名称 | BMC(Springer Nature) | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR |