{"created":"2023-06-19T13:30:54.440992+00:00","id":845,"links":{},"metadata":{"_buckets":{"deposit":"a90d0f34-cb9f-4fb4-8993-b77729a8dcd1"},"_deposit":{"created_by":14,"id":"845","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"845"},"status":"published"},"_oai":{"id":"oai:jrckicn.repo.nii.ac.jp:00000845","sets":["15"]},"author_link":["1620","1618","1616","1617","1633","1656","1629","1622","1623"],"control_number":"845","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"378","bibliographicPageStart":"370","bibliographicVolumeNumber":"118","bibliographic_titles":[{"bibliographic_title":"Life sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims:\nEndothelin-1 (ET-1) is a mediator of various physiological and pathological processes, including vascular inflammation, cell proliferation and vasoconstriction. Attenuation of ET action using ET-1 antagonists reduces pulmonary vascular leakage and inflammation in several models of lung injuries and experimental acute respiratory distress syndrome (ARDS). Based on these earlier reports, the current study investigates the patterns of ET-1 levels in circulation and pulmonary tissues in an experimental model of lavage-induced surfactant-depleted lung injury. Additionally, we also test the effects of open endotracheal suctioning (OES) and hyperinflation (HI) as recruitment maneuver following OES on ET-1 levels.\n\nMain methods:\nBriefly, 24 Japanese white rabbits were anesthetized and intubated. Normal saline was instilled into the lung and washed mildly. After instillation, rabbits were ventilated at definite settings at a total duration of 3 hours. OES and HI were performed every 15 minutes from the beginning of the protocol.\n\nKey findings:\nHere, we show that both circulatory and pulmonary ET-1 levels increased in models with lung injury induced by saline lavage compared to healthy control group. No further aggravation in expression of pulmonary ET-1 was seen after OES and HI, although OES and HI worsened arterial hypoxygenation and severity of lung injury. In contrast, circulatory ET-1 levels significantly decreased after OES and HI but were not associated with blood pressure changes.\n\nSignificance:\nWe conclude that in a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased. Further, OES and HI exerted differential effects on ET-1 expression at both circulatory and pulmonary levels.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Science Direct(Elsevier)"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.lfs.2014.04.001","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2014 Elsevier Inc."},{"subitem_rights":"Under a Creative Commons license Attribution-NonCommercial-NoDerivs 4.0 Unported (CC BY-NC-ND 4.0)"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00717011","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0024-3205","subitem_source_identifier_type":"PISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KAMIYAMA, Junko","creatorNameLang":"en"},{"creatorName":"神山, 純子","creatorNameLang":"ja"},{"creatorName":"カミヤマ, ジュンコ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jesmin, Subrina","creatorNameLang":"en"},{"creatorName":"荒井, サブリナ","creatorNameLang":"ja"},{"creatorName":"アライ, サブリナ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAKURAMOTO, Hideaki","creatorNameLang":"en"},{"creatorName":"櫻本, 秀明","creatorNameLang":"ja"},{"creatorName":"サクラモト, ヒデアキ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SIMOJO, Nobutake","creatorNameLang":"en"},{"creatorName":"下條, 信威","creatorNameLang":"ja"},{"creatorName":"シモジョウ, ノブタケ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Islam, Majedul","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Khatun, Tanzila","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{}]}],"creatorNames":[{"creatorName":"OKI, Masami","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWANO, Satoru","creatorNameLang":"en"},{"creatorName":"河野, 了","creatorNameLang":"ja"},{"creatorName":"カワノ, サトル","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIZUTANI, Taro","creatorNameLang":"en"},{"creatorName":"水谷, 太郎","creatorNameLang":"ja"},{"creatorName":"ミズタニ, タロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-07-12"}],"displaytype":"detail","filename":"Assessment of circulatory and pulmonary endothelin-1 levels in a lavage-induced surfactant-depleted lung injury rabbit model with repeated open endotracheal suctioning and hyperinflation.pdf","filesize":[{"value":"827.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"本文","url":"https://jrckicn.repo.nii.ac.jp/record/845/files/Assessment of circulatory and pulmonary endothelin-1 levels in a lavage-induced surfactant-depleted lung injury rabbit model with repeated open endotracheal suctioning and hyperinflation.pdf"},"version_id":"182eff0b-472b-4da6-943f-d7abef3dfe12"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"endothelin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lung injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"arterial oxygenation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"open endotracheal suctioning","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hyperinflation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Assessment of circulatory and pulmonary endothelin-1 levels in a lavage-induced surfactant-depleted lung injury rabbit model with repeated open endotracheal suctioning and hyperinflation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Assessment of circulatory and pulmonary endothelin-1 levels in a lavage-induced surfactant-depleted lung injury rabbit model with repeated open endotracheal suctioning and hyperinflation","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"14","path":["15"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-07-12"},"publish_date":"2022-07-12","publish_status":"0","recid":"845","relation_version_is_last":true,"title":["Assessment of circulatory and pulmonary endothelin-1 levels in a lavage-induced surfactant-depleted lung injury rabbit model with repeated open endotracheal suctioning and hyperinflation"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2024-02-02T06:43:16.057244+00:00"}