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We have previously shown that ET-1 is highly up-regulated in renal tissues and in plasma after LPS administration. Here, we investigated whether landiolol hydrochloride, an ultra-short-acting beta-blocker, can play an important role in ameliorating levels of LPS-induced up-regulation of renal HIF-1α–ET-1 system and inflammatory cytokines in a rat model of endotoxemia.\n\nMain methods\nMale Wistar rats at 8 weeks of age were either administered with: a) lipopolysaccharide (LPS) only for three hours (3 h) or b) LPS, followed by continuous administration of landiolol for 3 h; c) third group was only treated with vehicle.\n\nKey findings\nAt 3 h after LPS administration there was: a) minimal injury in kidney tissues; b) circulatory levels of creatinine, blood urea nitrogen and NGAL increased and c) expression of inflammatory cytokines, such as TNF-α, IL-6 and iNOS increased at the level of both circulatory and renal tissues. 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Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia
https://jrckicn.repo.nii.ac.jp/records/843
https://jrckicn.repo.nii.ac.jp/records/843e1273673-49fd-4aa0-ac39-1a3912e991d2
名前 / ファイル | ライセンス | アクション |
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本文 (772.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-07-12 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | kidney | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | landiolol hydrochloride | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endothelin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endotoxemia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | rat model | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
小倉, 吉保
× 小倉, 吉保× 荒井, サブリナ× 山口, 直人× OKI, Masami× 下條, 信威× Islam, Majedul× Khatun, Tanzila× 神山, 純子× 櫻本, 秀明× 萩谷, 圭一× 河野, 了× 水谷, 太郎 |
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抄録 | ||||||
内容記述 | Aims Endothelin (ET)-1 is the best known potent vasoconstrictor and has been implicated in pathogenesis of sepsis-associated acute kidney injury (AKI) in human or lipopolysaccharide (LPS)-induced AKI in animal models. We have previously shown that ET-1 is highly up-regulated in renal tissues and in plasma after LPS administration. Here, we investigated whether landiolol hydrochloride, an ultra-short-acting beta-blocker, can play an important role in ameliorating levels of LPS-induced up-regulation of renal HIF-1α–ET-1 system and inflammatory cytokines in a rat model of endotoxemia. Main methods Male Wistar rats at 8 weeks of age were either administered with: a) lipopolysaccharide (LPS) only for three hours (3 h) or b) LPS, followed by continuous administration of landiolol for 3 h; c) third group was only treated with vehicle. Key findings At 3 h after LPS administration there was: a) minimal injury in kidney tissues; b) circulatory levels of creatinine, blood urea nitrogen and NGAL increased and c) expression of inflammatory cytokines, such as TNF-α, IL-6 and iNOS increased at the level of both circulatory and renal tissues. In addition, LPS significantly induced renal expression of ET-1 and HIF-1α compared to control. Finally, treatment of LPS-administered rats with landiolol for 3 h normalized elevated serum markers of renal injury and up-regulated levels of renal HIF-1α–ET-1 system with normalization of TNF-α. Significance Taken together, these data led us to conclude that landiolol ameliorates the up-regulation of HIF-1α–ET-1 system in minimally morphologically-injured kidney and normalizes biomarkers of renal injury in early hours of endotoxemia of a rat model. |
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書誌情報 |
en : Life sciences 巻 118, 号 2, p. 347-356, 発行日 2014-11 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0024-3205 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00717011 | |||||
権利 | ||||||
権利情報 | Copyright © 2014 The Authors. Published by Elsevier Inc. | |||||
権利 | ||||||
権利情報 | Under a Creative Commons license Attribution-NonCommercial-NoDerivs 4.0 Unported (CC BY-NC-ND 4.0) | |||||
他の資源との関係 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.lfs.2014.05.007 | |||||
関連名称 | Science Direct(Elsevier) | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR |